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CBD vs CB2

Our article – CBD vs. CB2, can aid you know more about CBD, as well as CB2. To present this article to you, we did profound research on both of them.

Have a look.

Let’s start with CBD.

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What is CBD?

Cannabidiol, in short, CBD is a chemical component, which is existing in the cannabis plant. This is a substance, which occurs naturally and is useful for making many products like edibles, oils, lotions, etc.

These products are for imparting a feeling of calm and relaxation. Unlike the other main marijuana compound, THC, CBD is non-psychoactive.

Will It Produce The Feeling of High?

As we wrote above that this is a non-psychoactive component, it will not produce high.

The cannabis plants contain two major cannabinoids – THC and CBD.

Junella Chin, DO, a medical cannabis expert for cannabisMD and an osteopathic physician, says that the CBD is an anti-psychoactive component of the plant, and as a result, it will not have any euphoric effects.

In contrast to this, some people report that they experienced some side effects after consuming CBD. Therefore, to avoid this, consult a physician, before taking this supplement.

Moreover, it’s also essential that you should buy only the third-party tested cannabidiol products. This will ensure the quality of the product. Not only this, but it also proves that the product doesn’t contain herbicides, pesticides, as well as other harmful substances.

Know the Health Benefits of This Cannabinoid

When it comes to medication, the one and only FDA-approved CBD medication is Epidiolex. The FDA approved this medication for treating various forms of epilepsy.

However, as per some studies, many people reported that CBD comes from the extraction of hemp plants had helped them in managing some other health conditions as well. This includes osteoarthritis, back pain, and even cancer.

Let’s have a close look at the health conditions, for which CBD can be a beneficial option.

It can lessen the risk of cancer:

In a 2012 study in animals, it’s found that the animals treated with this medication, were significantly less likely to have colon cancer.

In addition to this, many other studies are showing that CBD can kill the cells, which causes cancer. Not only this, but it may also slow down the growth of cancerous tumors.

It can diminish the possibility of obesity and diabetes:

Many studies are stating that using cannabis on a regular basis can lead to reduced waist circumference, lower body mass index, and reduced risk of obesity and diabetes.

Research also shows that CBD can cause weight loss by converting the body’s white fat into brown fat (weight-reducing). This, in turn, promotes the production of noatherogenesisrmal insulin and sugar metabolism.

It can be a solution to treat broken bones and bone disease:

Cannabinoids are facilitative of the bone metabolism process. This process is the cycle in which the old bone material replaces by new. It is an essential thing to maintain healthy and strong bones over time.

As per the research, CBD can block the enzyme, which destroys the compound associated with bone-building in the body. This, as a result, can lessen the possibility of age-related bone disorders like osteoarthritis and osteoporosis.

CBD can help in the process of formation of new bone cells, and this is the reason why it’s believed that it can speed up the healing process of broken bones.

Stress and Anxiety

According to research, the oral use of both CBD and cannabis for managing anxiety disorder appears in a Vedic text, which is dated around 2000 BCE.

Studies show that the effect of cannabidiol can lessen the anxiety when it’s present in a high amount in the plant cannabis sativa.

From a research review in 2012, it’s clear that cannabidiol can lessen the level of anxiety (mainly social anxiety).

Furthermore, in an animal study related to the endocannabinoid system (ECS) and stress, researchers penned that the augmentation of ECS can be an efficient strategy to alleviate the physical, as well as, behavioral consequences associated with stress.

It may safeguards and heals the skin problems

The skin is that part of the body, which has high concentration and amount of cannabinoid type 2 receptors. When medications applied topically using serum, lotion, salve, oil, etc. the antioxidant present in CBD hemp oil can repair the damages occurring due to the free radicals such as environmental pollutants and UV rays. [The antioxidant in cannabidiol oil is more potent than vitamins C and E].

The topical products, which are cannabis-based, can treat many skin issues ranging from acne to psoriasis. Not only this, but it can also speed up the healing process of damaged skin.

Moreover, some people are reporting that making use of CBD oils and concentrated cannabis can treat melanoma, as well as carcinoma-type skin cancer.

It can lessen the risk of cardiovascular disease

Research states that cannabidiol can be a promising option for managing cardiovascular disease. This is because it can reduce blood pressure and control inflammation.

As per the researchers, one of the cardiovascular benefits of CBD is that it can reduce the resting blood pressure, as well as the blood pressure associated with stressful stimuli.

Anti-Inflammatory

Numerous studies are stating that CBD has anti-inflammatory properties. To decrease the inflammation systematically, cannabidiol interacts with the ECS in several organs all over the body.

While reading about this cannabinoid, another important thing, you must know is that it’s available in various forms. This helps the people to use it according to their convenience.

Please have a look at it.

Know the Different Forms of CBD

Here are the most common forms of cannabidiol:

Oils and Tinctures

These forms, mainly oils, are the prevalent and preferred method of many people to intake cannabidiol. To consume this, you have to place the oil drops under your tongue.

This method can make the absorption process fast.

Pills and Capsules

The pills and capsules are for the systemic treatment of digestive issues and seizure disorders.

Furthermore, as we wrote above, recently, the Food and Drug Administration of the United States approved the first CBD-drug (Epidiolex) to manage seizure disorders.

Vaping

Vaping CBD oil can be the quickest way to experience the effects of CBD. Through this way, the compounds will absorb directly from your lungs into the bloodstream.

Edibles

Gummies or edibles are one of the most prevalent methods to enjoy the effects of cannabidiol. Moreover, these are portable, tasty, affordable, and discrete.

Lotions and Creams

CBD-infused topical products such as lotions, creams, etc. can help provide joint pain relief. Not only this, but they can also treat several skin conditions such as psoriasis and eczema.

We hope you understand what CBD is.

Now, let’s dive into CB2 receptors.

What is CB2 (Cannabinoid Receptor Type 2)?

Cannabinoid receptor type 2, in short CB2, refers to be G protein-coupled receptor. It’s also from the family of the cannabinoid receptor and has a close connection with the cannabinoid receptor type 1 (CB1).

CB1 is responsible for the effectiveness of the psychoactive effects of THC (tetrahydrocannabinol). THC is the active psychoactive agent in cannabis.

The main endogenous ligand of type 2 cannabinoid receptor is 2-arachidonoylglycerol (2-AG).

Structure of CB2

The CNR2 gene encodes this cannabinoid receptor. It consists of nearly 360 amino acids, which makes it a little shorter as compared to the 473-amino-acid-long CB1.

This receptor has 7 transmembrane spanning domains, an intracellular C-terminus, and a glycosylated N-terminus. The C-terminus plays a vital role in regulating ligand-induced receptor desensitization and downregulation, followed by repeated agonist application.

The CB1 and CB2 receptors of humans possess around 44% similarity in amino acids. This similarity will reach approximately 68% when the receptor’s transmembrane regions are well-thought-out. While comparing with the sequence of amino acids of CB1, the sequence of the amino acids of cannabinoid receptor type 2 is less preserved across rodent species and humans.

According to the computer modeling, interactions of the ligand with the CB2 receptor remains F5.46 and S3.31. This can be the reason to find out the differences between the selectivity of both the receptors.

When it comes to CB2 receptors, lipophilic groups work with the F5.46 residue, which enables them to create a hydrogen bond with S3.31 residue. This can cause a conformational change in the structure of the receptor that triggers the beginning of several intracellular signaling paths.

Mechanism of This Cannabinoid Receptor

While comparing with CB1 receptors, CB2 receptors also constrain the adenylyl cyclase activity via Gi/Goα subunits.

It’s also believed that cannabinoid receptors type 2 couples with the pathway of MAPK-ERK through the Gβγ subunits. This pathway tends to be the highly conversed and complex pathway for signal transduction, which regulates several essential cellular processes in developing, as well as mature tissues.

The activation of this pathway with the help of CB2 receptor agonists, which is acting through the Gβγ subunit will result in certain changes in the migration of cells. Not only this, but it can also cause a stimulation of the growth-related gene Zif268.

This particular gene encrypts a transcriptional regulator involved in long-term memory formation and neuroplasticity.

As of now, five cannabinoids are produced endogenously all over the body. This includes 2-arachidonoyl glycerol (2-AG), virodhamine, 2-arachidonyl glyceryl ether, Arachidonoylethanolamine (anandamide), as well as the N-arachidonoyl-dopamine (NADA) [recently discovered].

Most of these ligands exhibit the functional selectivity properties at the CB2 receptor: 2-AG. It mainly activates the MAPK-ERK pathway, whereas noladin inhibits the adenylyl cyclase.

Role of CB2 Receptor in Regulating Inflammation

This cannabinoid receptor tends to be the peripheral receptor for the cannabinoids. It is mainly present in the immune tissues, which, in turn, highlights that the endocannabinoid system has the role of immunomodulatory.

Concerning this, the particular receptor was shown to control the functions of the immune cells in cellulo, as well as, animal models of the inflammatory disorders.

Many studies reveal that mice having lack of CB2 receptors have an exacerbated inflammatory phenotype. This indicates that the medical strategies, which aim at controlling CB2 signaling, can be promising for treating several inflammatory conditions.

Though we wrote almost everything about CBD and CB2, still we’re presenting a short comparison on both of them.

This comparison can provide you a basic idea of both in short.

Comparison between Cannabidiol and Cannabinoid Receptor Type 2

CBDCB2
1. Cannabidiol (CBD) is the non-psychoactive compound in the cannabis plant.1. Cannabinoid receptor type 2, in short CB2, is a G-protein coupled receptor from the family of the cannabinoid receptor.
2. CBD doesn’t interact with the CB2 receptors directly; instead it alters the ability of receptors to bind to the cannabinoids.2. CB2 receptors are mainly present in the white blood cells, spleen, and tonsils.
3. It can be a solution for treating anxiety, seizure, depression, etc.3. It can play a significant role in controlling the neurodegenerative diseases like Alzheimer’s disease.

Conclusion

This article can be a comprehensive guide for cannabidiol, as well as CB2 receptors. Therefore, please read this article thoroughly and gain knowledge about both.

Though we wrote almost everything about both of them, still there is a chance that some people may feel confusion in some aspects.

If you’re one among them, then contact us as soon as possible.

We are here to help you!

Disclaimer:

**The statements given in this are not from any medical expert. These are strictly based on our researches. The product is not for diagnosing, curing, treating, or preventing any health ailments. Before ingesting it, consulting a doctor would be an excellent decision. **

Reference Links:

1. https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075023/

3. https://www.health.com/pain/what-is-cbd

4. https://www.consciouslifestylemag.com/cbd-health-benefits/

5. https://www.royalqueenseeds.com/blog-cbd-a-potential-therapeutic-for-cardiovascular-diseases-n958

6. https://www.healthline.com/health/your-cbd-guide#dosage

7. https://www.news-medical.net/health/Cannabinoid-Receptors.aspx

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