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7 mins read; Research Time: 96 hours

CBD and CBDA are cannabinoids or unique components, which can come from marijuana and hemp plants. Though they both are cannabinoids, they have some dissimilarities.

Thus, to give you a clear idea of both and how they differ from each other, we’re presenting this article – CBD vs CBDA.

First, we’ll discuss CBD.


What is Cannabidiol (CBD)?

Cannabidiol is an anti-psychoactive cannabinoid, which can come from hemp, as well as cannabis. This anti-psychoactive cannabinoid has several medicinal properties. Thus, it can be a better solution to deal with a number of health ailments.

Cannabidiol coming from hemp will not produce the sensation of high like THC. THC is another active, but psychoactive compound in the cannabis plant.

In terms of medications, although it can help manage several health conditions, the FDA approved a CBD-drug to manage only a severe and rare type of seizures.

How Does This Active Component Works?

Cannabidiol works by interacting with the endocannabinoid system (ECS) present in the body of every individual. The ECS refers to be a regulating system, which contains cannabis-like molecules that occurs naturally.

This system works like neurotransmitters, which is responsible for sending messages all over the body to help sustain homeostasis.

Whenever cannabidiol interacts with the ECS, it interacts with the cannabinoid receptors (CB1 and CB2) present in it. While discussing this cannabinoid and its products, its legal status always comes out as a vital topic.

Concerning this, we include a subtopic to explain its legal status.

Realize the Health Benefits of Cannabidiol

In this current scenario, the popularity of CBD is increasing day by day. The main reason behind this is the medical properties associated with it.

According to research, it can help manage several ailments ranging from anxiety to even cancer. Moreover, early experiments also suggest that it could help combat anxiety,lessen pain, as well as can lessen the symptoms of schizophrenia.

In addition to this, an important aspect about CBD is, last year FDA-approved the first CBD-rich medication called Epidiolex. This medication is for treating Dravet and Lenox-Gastaut syndromes. These are the two severe and rare types of epilepsy.

How to Make Use of This Active Component

You can use this in several ways, as it has diverse forms. Some of the common methods are:

  • Tinctures and Oils: These are the concentrated and processed types of cannabidiol. In these forms, you’ve to place the drops underneath the tongue. Moreover, through this method, cannabidiol absorbs directly into the bloodstream.
  • Topical: Topical products are CBD creams, CBD lotions, CBD salves, and oils. You can apply these products directly into the affected areas of your body.
  • CBD Edibles: A range of products comes under this. You can eat CBD-infused edibles like chocolates or CBD gummies.
  • CBD Vape: In this method, you have to inhale a vaporized liquid, which contains CBD hemp oil.
  • Capsules and Pills: These products look the same as other capsules, and they contain CBD isolate or pure CBD oil. You can consume these products orally.

Is This Cannabinoid Has Any Side Effects?

As per the World Health Organization report in 2017, CBD can be a pure, safe, and even tolerable in high dosage. It may not cause any side effects.

Moreover, as per the NIH (National Institutes of Health), even 1,500 mg of cannabidiol can be safe to use daily up to four weeks.

However, there is a possibility that this cannabinoid can cause some side effects.

It includes:

  • Interaction of Drug: According to some experts, cannabidiol may quickly interfere with certain other prescription medications.
  • CBD Side Effects: The side effects include low blood pressure, drowsiness, dry mouth, and lightheadedness.

** Disclaimer: Talk to your trustworthy physician before consuming CBD products. **

Know From Where to Buy These Products?

There are several online and offline portals now from where you can get these products.

However, be careful while buying. You should check the ingredients first. This will help you to ensure that whether the product contains hemp CBD or not.

Moreover, you must also check that the product is lab-tested or not.

When it comes to buying online, you can consider Goto Leaf. The products available here are THC-free, Non-GMO, and third-party tested. In addition to this, we also provide lab-tested reports to our customers for their chosen cannabidiol product.

Now, let’s discuss CBDA.



What is Cannabidiolic Acid (CBDA)?

When it comes to cannabinoids of the cannabis plant, then you must be aware that there are near about 113 different cannabinoids. Among those, many are having a variety of medicinal effects.

CBDA is also one of those 113 compounds, but unfortunately, there is only a little information about this. It’s because the majority of research is focusing on THC and CBD.

The cannabinoids have acidic form as well. Actually, when the acidic forms are exposed to heat, they convert into a cannabinoid. For example; CBDA and THCA refers to be acidic cannabinoids and cannabidiol, as well as THC refer to be their active cannabinoids. The name for this process is decarboxylation.

Though there are no sufficient clinical trials on CBD, several patients of medical cannabis are using cannabidiol as their primary treatment option.

Now, you may think that like cannabidiol, whether CBDA also has medical benefits. If you have this doubt then, read the next subtopic and know the medical benefits of this acidic form.

Medical Research on CBDA

As of now, many studies are stating that cannabidiol can be an alternative option for curing many health ailments. However, this is not the condition for CBDA.

CBDA is just an unaltered form, which has carboxylic acid attached to it. THC is also there in the same raw form, as THCA. THCA may not produce any euphoric effect if it’s taken in oral form and also has diverse effects as compared to THC.

Moreover, as per some medical researches, CBDA can potentially treat nausea,inflammation, as well as cancer.

As we have mentioned about the CBDA benefits, let’s have a closer look at it.

Understand the Medical Benefits of This Cannabinoid


According to a study covered in the British Journal of Pharmacology, CBDA can lessen nausea and vomiting. It got clear from the experiment done in rats. Moreover, the research shows that as compared to cannabidiol, cannabidiolic acid can have more effectiveness at hindering vomiting in shrews and nausea in rats.

Furthermore, it may also manage anticipatory nausea. Until now, no treatment is available for this ailment.


In 2008, a research article covered in Drug Metabolism and Disposition states that this acid can be a selective COX-2 inhibitor. This aspect came into limelight by medicinal biochemists and chemists.

According to Green Flower, COX-2 tends to be an enzyme liable for inflammation and is also targeted by non-steroidal anti-inflammatory medicines. These medicines include ibuprofen and aspirin.

Moreover, the research reveals that cannabidiolic acid can block the COX-2 enzyme.


Along with the research on other cannabinoids, CBDA also needs research, mainly for its effectiveness in managing psychotic disorders.

Though the researches are less, a biopharmaceutical company has a patent on this cannabinoid in the treatment of psychic disorders.


As per the data presented by the National Center for Biotechnology Information in 2012, CBDA can offer a potential therapeutic modality in the revocation of cancer cell migration, which includes aggressive breast cancer as well.

Moreover, research also states that this acid is a biologically active chemical compound, which can be an efficient anti-migration agent.



How to Make Use of This Acidic Form

CBDA can be present at a high level in the raw materials coming from the high-CBD cultivars. These cultivars include CBD-dominant plants, which are sold in legal, as well as medical cannabis dispensaries and the hemp cultivars.

To include this in your regular diet, there are many ways. The ways are:

  • Juices
  • Salads
  • Tinctures
  • Garnishes
  • Smoothies
  • Cold sauces

And a lot more.

As the article is on CBD vs CBDA, we’re mentioning here the difference between both.

However, before getting into the difference, know its connection first.

Determine the Connection between Cannabidiol and Cannabidiolic Acid

In this section, first, you should know how they both are naturally connected with each other. Cannabidiolic acid is present in the raw plant material and is also the acidic predecessor to the active cannabidiol.

Initially, both of these cannabinoids develop in the plant cannabis as CBGA. After this, the synthase of cannabidiolic acid converts the CBGA to CBDA, and then the formation of cannabidiol takes place. This formation takes place through the decarboxylation process, in which the heat is applied to eliminate the carboxyl group.

This process can happen all of a sudden. For example; it can happen even when cooking or vaporizing.

Next, the difference between them.

Know the Difference between CBDA and CBD

When discussing these both, an important thing that you must know is they both are non-psychotropic. It means both of them neither make the users high nor affect their thought process.

Though in the primary stage, CBDA came out as an inactive component, it can present some amazing potential of its own.

Like cannabidiol and other cannabinoids, cannabidiolic acid can also have anti-inflammatory, as well as antiproliferative qualities.

Finally, we are presenting a short comparison of both. This will be a good stuff for you to have a basic idea on both the cannabinoids.

Comparison between Cannabidiol and Cannabidiolic Acid

1. CBD is one among the two main active cannabinoids in cannabis plants.1. Cannabidiolic acid is one among the 113 compounds in the cannabis plant and is also the acidic form of active component CBD.
2. Research shows it has many medicinal properties.2. Studies are very less on this, but still few research says that it has some medical benefits.
3. It can be a treatment option for stress, anxiety, insomnia, etc.3. It can be a treatment option for nausea, inflammation, cancer, etc.

Final Thoughts About CBDA and CBD

Whenever you start exploring the world of cannabis, you’ll come across many aspects of cannabis. One such aspect is the cannabinoids present in it.

As we wrote earlier, it has approx. 113 cannabinoids. Cannabidiol and CBDA also come under those cannabinoids.

Cannabidiol is the active cannabinoid, and cannabidiolic acid is the acidic form of cannabidiol. You can get a clear idea of this in the article as we did comprehensive research on both the cannabinoids before starting this article.

Still, if you feel like this article is incomplete, you can contact us and let us know what we missed out.

We’ll try our best to cover the particular topic.


** The statements given in this are not from any medical expert. These are strictly based on our researches. The product is not for diagnosing, curing, treating, or preventing any health ailments. Before ingesting it, consulting a doctor would be an excellent decision. **

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